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MDC1 抗体 (AA 475-525)

This anti-MDC1 antibody is a 兔 多克隆 antibody detecting MDC1 in WB 和 IP. Suitable for 人.
产品编号 ABIN7449894
发货至: 中国

Quick Overview for MDC1 抗体 (AA 475-525) (ABIN7449894)

抗原

See all MDC1 抗体
MDC1 (Mdc1 (MDC1))

适用

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宿主

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克隆类型

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多克隆

标记

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This MDC1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunoprecipitation (IP)
  • 抗原表位

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    AA 475-525

    原理

    Rabbit anti-MDC1 Antibody, Affinity Purified

    预测反应

    Monkey,Chimpanzee

    纯化方法

    Affinity Purified

    免疫原

    between AA 475 and 525

    亚型

    IgG
  • 应用备注

    IP: 2 - 10 μg/mg lysate

    WB: 1:10,000 - 1:25,000

    限制

    仅限研究用
  • 浓度

    1000 μg/mL

    缓冲液

    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    有效期

    12 months
  • 抗原

    MDC1 (Mdc1 (MDC1))

    别名

    MDC1

    背景

    Background: Mediator of DNA damage checkpoint protein 1 (Mdc1) is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It may serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. It is also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis [taken from the Universal Protein Resource (UniProt) Q5PSV9].

    基因ID

    9656

    NCBI登录号

    NP_055456

    UniProt

    Q14676
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