Stim2 抗体 (AA 650-700)
Quick Overview for Stim2 抗体 (AA 650-700) (ABIN7449833)
抗原
See all Stim2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 650-700
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原理
- Rabbit anti-STIM2 Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- Between AA 650 and 700
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亚型
- IgG
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应用备注
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IP: 2 - 10 μg/mg lysate
WB: 1:1,000 - 1:5,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- Stim2 (Stromal Interaction Molecule 2 (Stim2))
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别名
- STIM2
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背景
- Background: STIM2 (stromal interaction molecule 2) plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Stim2 functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. It regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, STIM2 translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI. STIM2 may inhibit STIM1-mediated Ca(2+) influx [taken from the Universal Protein Resource (UniProt) Q9P246].
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基因ID
- 57620
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NCBI登录号
- NP_065911
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UniProt
- Q9P246
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途径
- TCR Signaling, BCR Signaling
抗原
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