IWS1 抗体 (AA 1-50)
Quick Overview for IWS1 抗体 (AA 1-50) (ABIN7449756)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-50
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原理
- Rabbit anti-IWS1 Antibody, Affinity Purified
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预测反应
- Rat
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纯化方法
- Affinity Purified
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免疫原
- Between AA 1 and 50
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亚型
- IgG
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anti-IWS1 Homolog (IWS1) (AA 570-819) antibody
IWS1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-IWS1 Homolog (IWS1) (N-Term) antibodyIWS1 适用: 人, 大鼠, 小鼠, Cow, 犬, 山羊, 豚鼠, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-IWS1 Homolog (IWS1) antibodyIWS1 适用: 人 WB, ELISA, IHC 宿主: 兔 unconjugated
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应用备注
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IP: 2 - 10 μg/mg lysate
WB: 1:1,000 - 1:5,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- IWS1 (IWS1 Homolog (IWS1))
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别名
- IWS1
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背景
- Background: IWS1 homolog is a transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. IWS1 acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription [taken from the Universal Protein Resource (UniProt) Q96ST2].
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基因ID
- 55677
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NCBI登录号
- NP_060439
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UniProt
- Q96ST2
抗原
-
