CD45RO 抗体
Quick Overview for CD45RO 抗体 (ABIN7449553)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Mouse anti-CD45RO Monoclonal Antibody, Purified [UCHL-1]
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免疫原
- Cultured T-cells from an IL-2-dependent T-cell line (CA1)
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亚型
- IgG
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应用备注
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IHC-IF: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IHC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
ICC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.
WB: 05:10:00
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限制
- 仅限研究用
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浓度
- 50 μg/mL
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缓冲液
- Phosphate Buffered Saline (PBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- CD45RO
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别名
- CD45RO
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背景
- Background: CD45RO is also known as protein tyrosine phosphatase receptor type C (PTPRC). It is a protein tyrosine phosphatase required for T-cell activation through the antigen receptor. CD45RO acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, CD45RO recruits and dephosphorylates SKAP1 and FYN. It also dephosphorylates LYN, and thereby modulates LYN activity (By similarity)[taken from UniProtKB (Entry: P08575)].
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基因ID
- 5788
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NCBI登录号
- NP_002829
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UniProt
- P08575
抗原
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