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CD45RO 抗体

This anti-CD45RO antibody is a 小鼠 单克隆 antibody detecting CD45RO in IHC, WB, IF (p), ICC 和 mIF. Suitable for 人.
产品编号 ABIN7449553
发货至: 中国

Quick Overview for CD45RO 抗体 (ABIN7449553)

抗原

CD45RO

适用

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宿主

  • 57
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小鼠

克隆类型

  • 58
  • 12
单克隆

标记

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This CD45RO antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Multiplex Immunofluorescence (mIF)

克隆位点

UCHL-1
  • 原理

    Mouse anti-CD45RO Monoclonal Antibody, Purified [UCHL-1]

    免疫原

    Cultured T-cells from an IL-2-dependent T-cell line (CA1)

    亚型

    IgG
  • 应用备注

    IHC-IF: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

    IHC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

    ICC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.

    WB: 05:10:00

    限制

    仅限研究用
  • 浓度

    50 μg/mL

    缓冲液

    Phosphate Buffered Saline (PBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    有效期

    12 months
  • 抗原

    CD45RO

    别名

    CD45RO

    背景

    Background: CD45RO is also known as protein tyrosine phosphatase receptor type C (PTPRC). It is a protein tyrosine phosphatase required for T-cell activation through the antigen receptor. CD45RO acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, CD45RO recruits and dephosphorylates SKAP1 and FYN. It also dephosphorylates LYN, and thereby modulates LYN activity (By similarity)[taken from UniProtKB (Entry: P08575)].

    基因ID

    5788

    NCBI登录号

    NP_002829

    UniProt

    P08575
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