MCM4 抗体 (AA 325-375)
Quick Overview for MCM4 抗体 (AA 325-375) (ABIN7449391)
抗原
See all MCM4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 325-375
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原理
- Goat anti-MCM4 Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 325 and 375
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亚型
- IgG
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应用备注
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IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))
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别名
- MCM4
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背景
- Background: The MCM (Mini-Chromosome Maintenance) complex is a key component of the pre-replication complex involved in replication licensing which restricts DNA replication to only once per cell cycle. The MCM complex is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7. MCM4 is part of the core MCM complex that includes MCM4, MCM6, and MCM7. The core complex possesses DNA helicase activity. MCM4 is phosphorylated by CDC2 kinase resulting in a reduction of helicase activity and chromatin binding.
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基因ID
- 4173
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NCBI登录号
- NP_005905
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UniProt
- P33991
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途径
- DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
抗原
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