p40 (p63 Delta) (AA 1-50) 抗体
适用: 人
WB, IHC
宿主: 小鼠
Monoclonal
BC28
unconjugated
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- 抗原
- p40 (p63 Delta)
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抗原表位
- AA 1-50
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- 非结合性
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 原理
- Mouse anti-p40 Monoclonal Antibody [BC28]
- 免疫原
- between AA 1 and 50
- 克隆位点
- BC28
- 亚型
- IgG
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anti-p40 (p63 Delta) (AA 5-17) antibody
适用: 人, Cow, 小鼠, 大鼠 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
WB: 17:40:00
- 限制
- 仅限研究用
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- 浓度
- 250 μg/mL
- 缓冲液
- Phosphate Buffered Saline (PBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 有效期
- 12 months
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- 抗原
- p40 (p63 Delta)
- 别名
- p40
- 背景
- Background: Tumor protein p63 is a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. P63 is an extremely sensitive marker of lung squamous cell carcinoma, but it suffers from low specificity due to its reactivity in a substantial proportion of lung adenocarcinomas and other tumor types. P40 is a splice isoform of p63 known as DeltaNp63 and has been demonstrated to be highly specific for squamous/basal cells making it is markedly superior to p63 in specificity [adapted from NCBI Entrez Gene (Gene ID: 8626)].
- 基因ID
- 8626
- NCBI登录号
- NP_003713
- UniProt
- Q9H3D4
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