APOA1 抗体 (HRP)
Quick Overview for APOA1 抗体 (HRP) (ABIN7449327)
抗原
See all APOA1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Goat anti-Human Apo AI [H03] Antibody HRP Conjugated
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免疫原
- Human Apolipoprotein AI
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亚型
- IgG
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应用备注
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WB: 1:1,000 - 1:8,000
ELISA: 1:1,000 - 1:8,000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- 50 mM PBS, 0.1 M NaCl, and 0.01 % Thiomersal, pH 7.4
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- APOA1 (Apolipoprotein A-I (APOA1))
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别名
- ApoAI
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背景
- Background: Apo AI comprises approximately 70 % of the protein moiety in HDL. It is a single polypeptide chain consisting of 243 amino acid residues without disulfide bound and with glutamic acid as the C-terminal residue and aspartic acid as the N-terminal residue. The molecular weight is reported to be 28 kDa (Brewer et al., 1978). The roles of Apo AI in HDL function include reverse cholesterol transportation, lipid cholesterol binding, lecithin-cholesterol acyl transferase (LCAT) activation, and receptor binding, which is responsible for cholesterol esterification in plasma. Besides participate in cholesterol metabolism, Apo AI and HDL also suppress neutrophil activation, inhibit bacterial endotoxin, induce trypanosomal lysis, and other physiological activities. (Brouillette et al., 2001). Apo AI levels may be inversely related to the risk of coronary disease. In previous research, Apo AI may affect diet-induced inflammation by either directly or indirectly altering lipid rafts. (Cheng et al., 2012)
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基因ID
- 335
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NCBI登录号
- NP_000030
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UniProt
- P02647
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途径
- Regulation of Lipid Metabolism by PPARalpha, Production of Molecular Mediator of Immune Response, Lipid Metabolism
抗原
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