DIS3L2 抗体 (AA 475-525)
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北京 101111
Quick Overview for DIS3L2 抗体 (AA 475-525) (ABIN7449190)
抗原
See all DIS3L2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 475-525
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原理
- Rabbit anti-DIS3L2 Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 475 and 525
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亚型
- IgG
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应用备注
- 1:10,000 - 1:25,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))
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别名
- DIS3L2
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背景
- Background: DIS3L2 is a 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. [taken from the Universal Protein Resource (UniProt) Q8IYB7].
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基因ID
- 129563
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UniProt
- Q8IYB7
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途径
- Stem Cell Maintenance
抗原
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