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RRAGA 抗体 (AA 544-594)

This anti-RRAGA antibody is a 兔 多克隆 antibody detecting RRAGA in IHC 和 IF (p). Suitable for 人.
产品编号 ABIN7448966
发货至: 中国

Quick Overview for RRAGA 抗体 (AA 544-594) (ABIN7448966)

抗原

See all RRAGA 抗体
RRAGA (Ras-Related GTP Binding A (RRAGA))

适用

  • 27
  • 11
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  • 1

宿主

  • 27

克隆类型

  • 26
  • 1
多克隆

标记

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  • 1
  • 1
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This RRAGA antibody is un-conjugated

应用范围

  • 15
  • 14
  • 10
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  • 2
Immunohistochemistry (IHC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • 抗原表位

    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 544-594

    原理

    Rabbit anti-FIP1 IHC Antibody, Affinity Purified

    预测反应

    Bovine,Horse,Pig,Orangutan,Monkey,Gorilla,Chimpanzee,White-tufted-ear marmoset,Northern white-cheeked gibbon,Tasmanian devil

    纯化方法

    Affinity Purified

    免疫原

    Between AA 544 and 594

    亚型

    IgG
  • 应用备注

    IHC-IF: 1:50 - 1:500

    IHC: 1:100 - 1:500

    限制

    仅限研究用
  • 浓度

    100 μg/mL

    缓冲液

    Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    有效期

    12 months
  • 抗原

    RRAGA (Ras-Related GTP Binding A (RRAGA))

    别名

    FIP1

    背景

    Background: FIP1 was originally identified as Rhe (rearranged in hypereosinophilia) and part of a fusion protein encoded by a genetic rearrangement between the N-terminal region of FIP1 (Rhe) and the C-terminal region of the platelet-derived growth factor receptor alpha (PDGFRalpha). The fusion protein exhibits aberrant tyrosine kinase activity and is associated with hypereosinophilic syndrome (HES), a rare hematologic disorder characterized by an overproduction of eosinophils that results in organ damage. FIP1 was also identified as FIP1-like 1 in a database search for a human homolog of the yeast Fip1p (factor interacting with PAP), a subunit of the yeast 3'-end processing complex, CPF (cleavage and polyadenylation factor). Human FIP1 was similarly found to interact with PAP and CPSF160 as part of the human CPSF (cleavage and polyadenylation specificity factor) complex. In association with CPSF160, FIP1 is able to recognize U-rich elements on pre-mRNA and stimulate PAP activity.

    基因ID

    81608

    NCBI登录号

    NP_112179

    UniProt

    Q6UN15
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