ABL1 抗体 (AA 850-900)
Quick Overview for ABL1 抗体 (AA 850-900) (ABIN7448914)
抗原
See all ABL1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 850-900
-
原理
- Rabbit anti-cAbl IHC Antibody, affinity purified
-
预测反应
- Orangutan,Monkey,Gorilla,Chimpanzee,Crab-eating macaque,Northern white-cheeked gibbon,White-tufted-ear marmoset
-
纯化方法
- Affinity Purified
-
免疫原
- Between AA 850 and 900
-
亚型
- IgG
-
-
-
-
应用备注
-
ICC-IF: 1:50 - 1:500
IHC: 1:100 - 1:500
ICC: 1:100 - 1:500
-
限制
- 仅限研究用
-
-
-
浓度
- 250 μg/mL
-
缓冲液
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
有效期
- 12 months
-
-
- ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
-
别名
- cAbl
-
背景
- Background: c-Abl is the human cellular homolog of a the v-Abl viral oncogene. v-Abl was originally discovered as a mouse cell-derived sequence in the genome of the Abelson murine leukemia virus (A-MuLV), a transforming retrovirus isolated by the laboratory of Dr. H.T. Abelson. c-Abl is a tyrosine kinase from the Src-family of tyrosine kinases that localizes to both the cytoplasm and nucleus. It bears an SH2 (src-homology 2) and SH3 (src-homology 3) domain responsible for mediating c-Abl protein-protein interactions. c-Abl is implicated to play a role in multiple cellular processes such as cell cycle checkpoint signaling, apoptosis, cell differentiation, cell adhesion, and transcriptional regulation. Chromosomal translocations involving the c-Abl gene are associated with human leukemias.
-
基因ID
- 25
-
NCBI登录号
- NP_005148
-
UniProt
- P00519
-
途径
- Apoptosis, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism
抗原
-