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Presenilin 1 抗体

This anti-Presenilin 1 antibody is a 兔 单克隆 antibody detecting Presenilin 1 in WB. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN7384484
发货至: 中国

Quick Overview for Presenilin 1 抗体 (ABIN7384484)

抗原

See all Presenilin 1 (PSEN1) 抗体
Presenilin 1 (PSEN1)

适用

  • 104
  • 81
  • 59
  • 9
  • 9
  • 8
  • 6
  • 4
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
人, 小鼠, 大鼠

宿主

  • 95
  • 38
  • 2
  • 2
  • 2
  • 1

克隆类型

  • 130
  • 10
单克隆

标记

  • 61
  • 9
  • 9
  • 6
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This Presenilin 1 antibody is un-conjugated

应用范围

  • 109
  • 57
  • 52
  • 52
  • 39
  • 18
  • 18
  • 17
  • 13
  • 12
  • 9
  • 1
  • 1
Western Blotting (WB)

克隆位点

R05-4D4
  • 纯化方法

    Affinity Purified

    亚型

    IgG
  • 应用备注

    WB 1:1000-1:2000

    限制

    仅限研究用
  • 浓度

    300 μg/mL

    缓冲液

    50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原

    Presenilin 1 (PSEN1)

    别名

    Presenilin 1

    背景

    AD3,FAD,PS-1,PS1,S182,Presenilin 1,PSEN1,Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

    分子量

    Observed_MW: 20kDa

    Calculated_MW: 53kDa

    基因ID

    5663

    UniProt

    P49768

    途径

    Notch Signaling, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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