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Presenilin 1 抗体

PSEN1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Monoclonal R05-4D4 unconjugated
产品编号 ABIN7384484
发货至: 中国
  • 抗原 See all Presenilin 1 (PSEN1) 抗体
    Presenilin 1 (PSEN1)
    适用
    • 104
    • 81
    • 59
    • 9
    • 9
    • 8
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 95
    • 38
    • 2
    • 2
    • 2
    • 1
    克隆类型
    • 130
    • 10
    单克隆
    标记
    • 61
    • 9
    • 9
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Presenilin 1 antibody is un-conjugated
    应用范围
    • 109
    • 57
    • 52
    • 52
    • 39
    • 18
    • 18
    • 17
    • 13
    • 12
    • 9
    • 1
    • 1
    Western Blotting (WB)
    纯化方法
    Affinity Purified
    克隆位点
    R05-4D4
    亚型
    IgG
    Top Product
    Discover our top product PSEN1 Primary Antibody
  • 应用备注
    WB 1:1000-1:2000
    限制
    仅限研究用
  • 浓度
    300 μg/mL
    缓冲液
    50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    Presenilin 1 (PSEN1)
    别名
    Presenilin 1 (PSEN1 产品)
    背景
    AD3,FAD,PS-1,PS1,S182,Presenilin 1,PSEN1,Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
    分子量

    Observed_MW: 20kDa

    Calculated_MW: 53kDa

    基因ID
    5663
    UniProt
    P49768
    途径
    Notch Signaling, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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