KEAP1 抗体
Quick Overview for KEAP1 抗体 (ABIN7384390)
抗原
See all KEAP1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
- 
    
- 
                                            
纯化方法
 - Affinity Purified
 - 
                                            
亚型
 - IgG
 
 - 
                                            
 - 
    
 - 
    
- 
                                            
应用备注
 - WB 1:500-1:1000 IHC 1:20-1:50
 - 
                                            
限制
 - 仅限研究用
 
 - 
                                            
 - 
    
- 
                                            
浓度
 - 300 μg/mL
 - 
                                            
缓冲液
 - 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA
 - 
                                            
储存液
 - Sodium azide
 - 
                                            
注意事项
 - This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
 - 
                                            
储存条件
 - -20 °C
 - 
                                            
储存方法
 - Store at -20°C. Avoid freeze / thaw cycles.
 
 - 
                                            
 - 
    
- KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
 - 
                                            
别名
 - Keap1
 - 
                                            
背景
 - Cytosolic inhibitor of Nrf2,INrf 2,INrf2,Keap 1,KEAP1,KEAP1,Kelch like ECH associated protein 1,Kelch like family member 19,Kelch like protein 19,Kelch-like ECH-associated protein 1,Kelch-like protein 19,KIAA0132,KLHL 19,KLHL19,MGC10630,MGC1114,MGC20887,MGC4407,MGC9454,KEAP1,also named as INRF2,KIAA0132 and KLHL19,is part of a multiprotein complex that contains the CUL3-ROC1 ubiquitin ligase,which can ubiquitinate the N-terminal domain of NRF2. Two molecules of KEAP1 bind to two distinct sites in the N-terminal region of NRF2,the ETGE and DLG sites,which affect the KEAP1-NRF2 interaction and/or its physiological consequences. KEAP1 retains NFE2L2/NRF2 in the cytosol. It functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. It also retains BPTF in the cytosol. This antibody is a mouse monoclonal antibody raised against residues near the C terminus of human KEAP1.
 - 
                                            
分子量
 - 
                        
Observed_MW: 60/64kDa
Calculated_MW: 70kDa
 - 
                                            
基因ID
 - 9817
 - 
                                            
UniProt
 - Q14145
 - 
                                            
途径
 - Maintenance of Protein Location
 
抗原
 -