Coronavirus Spike Glycoprotein 抗体
CoV S
适用: Human Coronavirus HKU1 (HCoV-HKU1)
ELISA
宿主: 小鼠
Monoclonal
7
unconjugated
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- 抗原 See all Coronavirus Spike Glycoprotein (CoV S) 抗体
- Coronavirus Spike Glycoprotein (CoV S)
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适用
- Human Coronavirus HKU1 (HCoV-HKU1)
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Coronavirus Spike Glycoprotein antibody is un-conjugated
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应用范围
- ELISA
- 特异性
- Anti-Human coronavirus spike glycoprotein Monoclonal Antibody
- 纯化方法
- Protein A Affinity
- 免疫原
- Recombinant HCoV-HKU1 (Isolate N1) S1 Protein (His Tag), ABIN7198827
- 克隆位点
- 7
- 亚型
- IgG1
- Top Product
- Discover our top product CoV S Primary Antibody
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anti-Coronavirus Spike Glycoprotein (CoV S) antibody
CoV S 适用: SARS Coronavirus-2 (SARS-CoV-2) ELISA, WB, IF, IP 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- ELISA 1:1000-1:2000
- 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- 0.2 μm filtered solution in PBS
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- Coronavirus Spike Glycoprotein (CoV S)
- 别名
- coronavirus spike glycoprotein (CoV S 产品)
- 别名
- E2 antibody, E2 glycoprotein precursor antibody, S antibody
- 物质类
- Viral Protein
- 背景
- Spike,The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, dipeptidyl peptidase-4, APN, aminopeptidase N, CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1, Sia, sialic acid, O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion, Defines the range of the hosts and specificity of the virus, Main component to bind with the neutralizing antibody, Key target for vaccine design, Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
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