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SMN1 抗体 (AA 80-150)

This anti-SMN1 antibody is a 兔 多克隆 antibody detecting SMN1 in WB 和 IHC. Suitable for 人.
产品编号 ABIN7270652
发货至: 中国

Quick Overview for SMN1 抗体 (AA 80-150) (ABIN7270652)

抗原

See all SMN1 抗体
SMN1 (Survival of Motor Neuron 1, Telomeric (SMN1))

适用

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宿主

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克隆类型

  • 55
  • 19
多克隆

标记

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This SMN1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC)
  • 抗原表位

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    AA 80-150

    原理

    SMN1 Rabbit pAb

    序列

    SQKKNTAASL QQWKVGDKCS AIWSEDGCIY PATIASIDFK RETCVVVYTG YGNREEQNLS DLLSPICEVA N

    交叉反应

    人, 小鼠, 大鼠

    产品特性

    Polyclonal Antibodies

    纯化方法

    Affinity purification

    免疫原

    Recombinant fusion protein containing a sequence corresponding to amino acids 80-150 of human SMN1 (NP_000335.1).

    亚型

    IgG
  • 应用备注

    WB,1:500 - 1:2000,IHC,1:50 - 1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原

    SMN1 (Survival of Motor Neuron 1, Telomeric (SMN1))

    别名

    SMN1

    背景

    This gene is part of a 500 kb inverted duplication on chromosome 5q13. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy, mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Multiple transcript variants encoding distinct isoforms have been described.,SMN1,BCD541,GEMIN1,SMA,SMA1,SMA2,SMA3,SMA4,SMN1

    分子量

    27kDa/28kDa/30kDa/31kDa

    基因ID

    6606

    UniProt

    Q16637

    途径

    Ribonucleoprotein Complex Subunit Organization
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