SARM1 抗体
Quick Overview for SARM1 抗体 (ABIN7270591)
抗原
See all SARM1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- SARM1 Rabbit pAb
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交叉反应
- 人
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant protein of human SARM1.
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亚型
- IgG
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anti-Sterile alpha and TIR Motif Containing 1 (SARM1) (AA 340-380) antibody
SARM1 适用: 人, 小鼠, 大鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sterile alpha and TIR Motif Containing 1 (SARM1) (C-Term) antibodySARM1 适用: 人, 小鼠 WB, IHC (p), IF, ICC, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sterile alpha and TIR Motif Containing 1 (SARM1) (AA 93-292) antibodySARM1 适用: 人 IHC (p), IP, IHC 宿主: 小鼠 Monoclonal Sarmy-1 unconjugated
anti-Sterile alpha and TIR Motif Containing 1 (SARM1) (C-Term) antibodySARM1 适用: 人, 小鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000,IP,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))
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别名
- SARM1
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背景
- NAD(+ hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+ metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+ depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+ into ADP-D-ribose (ADPR, cyclic ADPR (cADPR and nicotinamide, NAD(+ cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP(+, but not other NAD(+-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.,SARM, HsTIR, SAMD2, hSARM1, MyD88-5,SARM1
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分子量
- 79kDa
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基因ID
- 23098
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UniProt
- Q6SZW1
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途径
- TLR signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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