Phospholamban 抗体 (pSer16, pThr17)
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北京 101111
Quick Overview for Phospholamban 抗体 (pSer16, pThr17) (ABIN7269330)
抗原
See all Phospholamban (PLN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer16, pThr17
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原理
- Phospho-PLN-S16/T17 Rabbit pAb
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Phosphorylated Antibodies
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纯化方法
- Affinity purification
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免疫原
- A synthetic phosphorylated peptide around of human Phospho-PLN-S16/T17.
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亚型
- IgG
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应用备注
- WB,1:500 - 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- Phospholamban (PLN)
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别名
- PLN
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背景
- The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.,CMD1P,CMH18,PLB,PLN,Cancer,Signal Transduction,Endocrine & Metabolism,Neuroscience,Calcium Signaling,Cardiovascular,Heart,Contractility,PLN
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分子量
- 6kDa
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基因ID
- 5350
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UniProt
- P26678
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途径
- Negative Regulation of Transporter Activity
抗原
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