NSMCE1 抗体 (AA 7-266)
Quick Overview for NSMCE1 抗体 (AA 7-266) (ABIN7268951)
抗原
See all NSMCE1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 7-266
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原理
- NSMCE1 Rabbit pAb
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序列
- RMGVMTDVHR RFLQLLMTHG VLEEWDVKRL QTHCYKVHDR NATVDKLEDF INNINSVLES LYIEIKRGVT EDDGRPIYAL VNLATTSISK MATDFAENEL DLFRKALELI IDSETGFASS TNILNLVDQL KGKKMRKKEA EQVLQKFVQN KWLIEKEGEF TLHGRAILEM EQYIRETYPD AVKICNICHS LLIQGQSCET CGIRMHLPCV AKYFQSNAEP RCPHCNDYWP HEIPKVFDPE KERESGVLKS NKKSLRSRQH
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交叉反应
- 人, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 7-266 of human NSMCE1 (NP_659547.2).
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亚型
- IgG
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anti-Non-SMC Element 1 Homolog (NSMCE1) (AA 1-256) antibody
NSMCE1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Non-SMC Element 1 Homolog (NSMCE1) (Center) antibodyNSMCE1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Non-SMC Element 1 Homolog (NSMCE1) (AA 81-130) antibodyNSMCE1 适用: 人, 小鼠, 大鼠, 豚鼠, 兔, 斑马鱼, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Non-SMC Element 1 Homolog (NSMCE1) (AA 143-192) antibodyNSMCE1 适用: 人, 小鼠, 大鼠, 豚鼠, Cow, 山羊, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Non-SMC Element 1 Homolog (NSMCE1) antibodyNSMCE1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- NSMCE1 (Non-SMC Element 1 Homolog (NSMCE1))
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别名
- NSMCE1
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背景
- RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair. MAGEF1-NSMCE1 ubiquitin ligase promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors.,NSMCE1,NSE1,NSE1 homolog,Epigenetics & Nuclear Signaling,DNA Damage & Repair,NSMCE1
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分子量
- 30kDa
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基因ID
- 197370
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UniProt
- Q8WV22
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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