IFI35 抗体 (AA 1-288)
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北京 101111
Quick Overview for IFI35 抗体 (AA 1-288) (ABIN7267962)
抗原
See all IFI35 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-288
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原理
- IFI35 Rabbit pAb
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序列
- MSAPLDAALH ALQEEQARLK MRLWDLQQLR KELGDSPKDK VPFSVPKIPL VFRGHTQQDP EVPKSLVSNL RIHCPLLAGS ALITFDDPKV AEQVLQQKEH TINMEECRLR VQVQPLELPM VTTIQVMMSS QLSGRRVLVT GFPASLRLSE EELLDKLEIF FGKTRNGGGD VDVRELLPGS VMLGFARDGV AQRLCQIGQF TVPLGGQQVP LRVSPYVNGE IQKAEIRSQP VPRSVLVLNI PDILDGPELH DVLEIHFQKP TRGGGEVEAL TVVPQGQQGL AVFTSESG
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交叉反应
- 人, 小鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-288 of human IFI35 (NP_005524.2).
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亚型
- IgG
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anti-Interferon-Induced Protein 35 (IFI35) (AA 189-288) antibody
IFI35 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3H6 unconjugated
anti-Interferon-Induced Protein 35 (IFI35) (AA 2-286) antibodyIFI35 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein 35 (IFI35) (C-Term) antibodyIFI35 适用: 人, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein 35 (IFI35) (AA 1-288) antibodyIFI35 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Interferon-Induced Protein 35 (IFI35) antibodyIFI35 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein 35 (IFI35) (AA 189-288) antibodyIFI35 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Interferon-Induced Protein 35 (IFI35) antibodyIFI35 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein 35 (IFI35) antibodyIFI35 适用: 人 DB 宿主: 小鼠 Monoclonal 2461C3a unconjugated
anti-Interferon-Induced Protein 35 (IFI35) (AA 15-42), (N-Term) antibodyIFI35 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB20477 unconjugated
anti-Interferon-Induced Protein 35 (IFI35) (AA 22-49), (N-Term) antibodyIFI35 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000,IF,1:50 - 1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- IFI35 (Interferon-Induced Protein 35 (IFI35))
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别名
- IFI35
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背景
- Acts as a signaling pathway regulator involved in innate immune system response. In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response, the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation. In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production. In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries. Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion. Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of proinflammatory cytokines.,IFI35,IFP35,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Cell differentiation,IFI35
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分子量
- 31kDa
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基因ID
- 3430
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UniProt
- P80217
抗原
-
