GAPVD1 抗体 (AA 1-260)
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北京 101111
Quick Overview for GAPVD1 抗体 (AA 1-260) (ABIN7267529)
抗原
See all GAPVD1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-260
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原理
- GAPVD1 Rabbit pAb
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序列
- MVKLDIHTLA HHLKQERLYV NSEKQLIQRL NADVLKTAEK LYRTAWIAKQ QRINLDRLII TSAEASPAEC CQHAKILEDT QFVDGYKQLG FQETAYGEFL SRLRENPRLI ASSLVAGEKL NQENTQSVIY TVFTSLYGNC IMQEDESYLL QVLRYLIEFE LKESDNPRRL LRRGTCAFSI LFKLFSEGLF SAKLFLTATL HEPIMQLLVE DEDHLETDPN KLIERFSPSQ QEKLFGEKGS DRFRQKVQEM VESNEAKLVA
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交叉反应
- 小鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human GAPVD1 (NP_056450.2).
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亚型
- IgG
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anti-GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) (AA 1-629) antibody
GAPVD1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) (N-Term) antibodyGAPVD1 适用: 人, 小鼠, 犬, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) (AA 182-231) antibodyGAPVD1 适用: 人, 小鼠, 犬, 大鼠, Cow, 豚鼠, 马, 兔, Bat, 小鸡, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) (N-Term) antibodyGAPVD1 适用: 人, 小鼠, 犬, 大鼠, Cow, 豚鼠, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) antibodyGAPVD1 适用: 小鼠 IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000,IF,1:50 - 1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))
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别名
- GAPVD1
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背景
- Acts both as a GTPase-activating protein (GAP and a guanine nucleotide exchange factor (GEF, and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras.,GAPVD1,GAPEX5,GAPex-5,RAP6,Cancer,Signal Transduction,G protein signaling,Signal Transduction,Endocrine & Metabolism,GAPVD1
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分子量
- 165kDa
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基因ID
- 26130
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UniProt
- Q14C86
抗原
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