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GAPVD1 抗体 (N-Term)

GAPVD1 适用: 人, 小鼠, 犬, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN630695
发货至: 中国
  • 抗原 See all GAPVD1 抗体
    GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))
    抗原表位
    • 15
    • 2
    • 2
    • 1
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    • 1
    • 1
    N-Term
    适用
    • 25
    • 5
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    • 3
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    • 1
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    人, 小鼠, 犬, 大鼠
    宿主
    • 24
    • 2
    克隆类型
    • 26
    多克隆
    标记
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    This GAPVD1 antibody is un-conjugated
    应用范围
    • 24
    • 13
    • 13
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    特异性
    GAPVD1 antibody was raised against the N terminal of GAPVD1
    纯化方法
    Affinity purified
    免疫原
    GAPVD1 antibody was raised using the N terminal of GAPVD1 corresponding to a region with amino acids FKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQ
    Top Product
    Discover our top product GAPVD1 Primary Antibody
  • 应用备注
    WB: 0.25 µg/mL, IHC: 4-8 µg/mL
    Optimal conditions should be determined by the investigator.
    说明

    GAPVD1 Blocking Peptide, catalog no. 33R-2950, is also available for use as a blocking control in assays to test for specificity of this GAPVD1 antibody

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Lyophilized powder. Add distilled water for a 1 mg/mL concentration of GAPVD1 antibody in PBS
    浓度
    Lot specific
    缓冲液
    PBS
    注意事项
    Avoid repeated freeze/thaw cycles.
    Dilute only prior to immediate use.
    储存条件
    4 °C/-20 °C
    储存方法
    Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
  • 抗原
    GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))
    别名
    GAPVD1 (GAPVD1 产品)
    别名
    zgc:92666 antibody, GAPEX5 antibody, RAP6 antibody, 2010005B09Rik antibody, 4432404J10Rik antibody, AW108497 antibody, Gapex-5 antibody, RME-6 antibody, mKIAA1521 antibody, RGD1307479 antibody, GTPase activating protein and VPS9 domains 1 antibody, GTPase activating protein and VPS9 domains 1 S homeolog antibody, LOAG_00609 antibody, GAPVD1 antibody, gapvd1 antibody, gapvd1.S antibody, Gapvd1 antibody
    背景
    GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras.
    分子量
    166 kDa (MW of target protein)
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