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TNNT3 抗体 (AA 147-256)

This anti-TNNT3 antibody is a 兔 多克隆 antibody detecting TNNT3 in WB. Suitable for 人.
产品编号 ABIN7267145
发货至: 中国

Quick Overview for TNNT3 抗体 (AA 147-256) (ABIN7267145)

抗原

See all TNNT3 抗体
TNNT3 (Fast Skeletal Troponin T (TNNT3))

适用

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宿主

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克隆类型

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多克隆

标记

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This TNNT3 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    AA 147-256

    原理

    TNNT3 Rabbit pAb

    序列

    SMGANYSSYL AKADQKRGKK QTAREMKKKI LAERRKPLNI DHLGEDKLRD KAKELWETLH QLEIDKFEFG EKLKRQKYDI TTLRSRIDQA QKHSKKAGTP AKGKVGGRWK

    交叉反应

    小鼠, 大鼠

    产品特性

    Polyclonal Antibodies

    纯化方法

    Affinity purification

    免疫原

    Recombinant fusion protein containing a sequence corresponding to amino acids 147-256 of human TNNT3 (NP_001036246.1).

    亚型

    IgG
  • 应用备注

    WB,1:200 - 1:2000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原

    TNNT3 (Fast Skeletal Troponin T (TNNT3))

    别名

    TNNT3

    背景

    The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein, also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B).,TNNT3,TNTF,troponin T3,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,TNNT3

    分子量

    29kDa/30kDa/31kDa

    基因ID

    7140

    UniProt

    P45378
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