TNNT3 抗体 (AA 147-256)
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北京 101111
Quick Overview for TNNT3 抗体 (AA 147-256) (ABIN7267145)
抗原
See all TNNT3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 147-256
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原理
- TNNT3 Rabbit pAb
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序列
- SMGANYSSYL AKADQKRGKK QTAREMKKKI LAERRKPLNI DHLGEDKLRD KAKELWETLH QLEIDKFEFG EKLKRQKYDI TTLRSRIDQA QKHSKKAGTP AKGKVGGRWK
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交叉反应
- 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 147-256 of human TNNT3 (NP_001036246.1).
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亚型
- IgG
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应用备注
- WB,1:200 - 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- TNNT3 (Fast Skeletal Troponin T (TNNT3))
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别名
- TNNT3
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背景
- The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein, also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B).,TNNT3,TNTF,troponin T3,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,TNNT3
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分子量
- 29kDa/30kDa/31kDa
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基因ID
- 7140
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UniProt
- P45378
抗原
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