CDK12 抗体 (AA 80-290)
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北京 101111
Quick Overview for CDK12 抗体 (AA 80-290) (ABIN7266230)
抗原
See all CDK12 (CRKRS) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 80-290
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原理
- CDK12 Rabbit pAb
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序列
- SDTFSDDMAF KLDRRENDER RGSDRSDRLH KHRHHQHRRS RDLLKAKQTE KEKSQEVSSK SGSMKDRISG SSKRSNEETD DYGKAQVAKS SSKESRSSKL HKEKTRKERE LKSGHKDRSK SHRKRETPKS YKTVDSPKRR SRSPHRKWSD SSKQDDSPSG ASYGQDYDLS PSRSHTSSNY DSYKKSPGST SRRQSVSPPY KEPSAYQSST R
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 80-290 of human CDK12 (NP_057591.2).
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亚型
- IgG
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anti-Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) (AA 1281-1380) antibody
CRKRS 适用: 人 ELISA, WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 3C1 unconjugated
anti-Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) (AA 1281-1380) antibodyCRKRS 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 1H4 unconjugated
anti-Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) antibodyCRKRS 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) (AA 1281-1380) antibodyCRKRS 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 2F6 unconjugated
anti-Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) (Internal Region) antibodyCRKRS 适用: 人, 犬, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) (AA 1309-1490) antibodyCRKRS 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) (C-Term) antibodyCRKRS 适用: 人, 大鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- CDK12 (CRKRS) (Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS))
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别名
- CDK12
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背景
- Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD of the large subunit of RNA polymerase II (POLR2A, thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.,CDK12,CRK7,CRKR,CRKRS,Cancer,Signal Transduction,Kinase,Tyrosine kinases,CDK12
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分子量
- 141kDa/163kDa/164kDa
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基因ID
- 51755
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UniProt
- Q9NYV4
抗原
-
