BRSK1 抗体 (AA 310-510)
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北京 101111
Quick Overview for BRSK1 抗体 (AA 310-510) (ABIN7265908)
抗原
See all BRSK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 310-510
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原理
- BRSK1 Rabbit pAb
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序列
- PSNGELDPDV LESMASLGCF RDRERLHREL RSEEENQEKM IYYLLLDRKE RYPSCEDQDL PPRNDVDPPR KRVDSPMLSR HGKRRPERKS MEVLSITDAG GGGSPVPTRR ALEMAQHSQR SRSVSGASTG LSSSPLSSPR SPVFSFSPEP GAGDEARGGG SPTSKTQTLP SRGPRGGGAG EQPPPPSARS TPLPGPPGSP R
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 310-510 of human BRSK1 (NP_115806.1).
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亚型
- IgG
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anti-BR Serine/threonine Kinase 1 (BRSK1) (AA 426-591) antibody
BRSK1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-BR Serine/threonine Kinase 1 (BRSK1) (AA 355-384) antibodyBRSK1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB40234 unconjugated
anti-BR Serine/threonine Kinase 1 (BRSK1) (Internal Region) antibodyBRSK1 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-BR Serine/threonine Kinase 1 (BRSK1) (AA 654-684), (C-Term) antibodyBRSK1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB5415 unconjugated
anti-BR Serine/threonine Kinase 1 (BRSK1) (C-Term) antibodyBRSK1 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))
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别名
- BRSK1
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背景
- Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2 at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.,BRSK1,hSAD1,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,BRSK1
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分子量
- 38kDa/85kDa/86kDa
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基因ID
- 84446
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UniProt
- Q8TDC3
抗原
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