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NPY1R 抗体 (2nd Extracellular Loop) (FITC)

This 兔多克隆 antibody specifically detects NPY1R in FACS 和 LCI. It exhibits reactivity toward 小鼠.

Cell surface detection of NPY1R by direct flow cytometry in live intact mouse J774 macrophage cell line: + Rabbit IgG isotype control-FITC. (NPY1R 抗体 (2nd Extracellular Loop) (FITC))

FACS

Cell surface detection of NPY1R by direct flow cytometry in live intact human monocytic leukemia cell line: + Rabbit IgG isotype control-FITC. (NPY1R 抗体 (2nd Extracellular Loop) (FITC))

FACS

2 images

产品编号 ABIN7237741

发货至: 中国

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Quick Overview for NPY1R 抗体 (2nd Extracellular Loop) (FITC) (ABIN7237741)

抗原

See all NPY1R 抗体

NPY1R (Neuropeptide Y Receptor Y1 (NPY1R))

适用

小鼠

宿主

兔

克隆类型

多克隆

标记

This NPY1R antibody is conjugated to FITC

应用范围

Flow Cytometry (FACS), Live Cell Imaging (LCI)

Discover our top product NPY1R Primary Antibody

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2nd Extracellular Loop, AA 197-210

原理

A Rabbit Polyclonal Antibody to NPY1R (extracellular) conjugated to the fluorescent dye FITC

交叉反应

人, 小鼠, 大鼠

预测反应

Rat - identical, human - 13,14 amino acid residues identical

产品特性

Extracellular, 2nd loop

纯化方法

Affinity purified on immobilized antigen.

免疫原

CFDKFPSDSHRLSY, corresponding to amino acid residues 197-210 of mouse NPY1R

亚型

IgG
anti-Neuropeptide Y Receptor Y1 (NPY1R) (AA 301-382) antibody
NPY1R 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Neuropeptide Y Receptor Y1 (NPY1R) (Middle Region) antibody
NPY1R 适用: 人, 小鼠, 大鼠, 马, 犬, 豚鼠, 兔, 绵羊, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Neuropeptide Y Receptor Y1 (NPY1R) (AA 1-115) antibody
NPY1R 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G2 unconjugated

anti-Neuropeptide Y Receptor Y1 (NPY1R) (AA 180-229) antibody
NPY1R 适用: 人, 小鼠, 大鼠, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Neuropeptide Y Receptor Y1 (NPY1R) antibody
NPY1R 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Neuropeptide Y Receptor Y1 (NPY1R) (Extracellular Domain) antibody
NPY1R 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Neuropeptide Y Receptor Y1 (NPY1R) (2nd Extracellular Loop), (AA 197-210) antibody
NPY1R 适用: 小鼠 WB, IHC, IF, FACS, LCI 宿主: 兔 Polyclonal unconjugated

anti-Neuropeptide Y Receptor Y1 (NPY1R) (C-Term) antibody
NPY1R 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Neuropeptide Y Receptor Y1 (NPY1R) (Cytoplasmic Domain) antibody
NPY1R 适用: 人, 小鼠, 大鼠, 马, 猴, 犬, 豚鼠, 兔, Pig, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Neuropeptide Y Receptor Y1 (NPY1R) (3rd Intracellular Loop), (AA 237-252) antibody
NPY1R 适用: 人 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated

应用备注

WB: The optimal concentration should be determined by the user
FC: 2.5-5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user

说明

Negative Control: (ABIN7582044)
Blocking Peptide: (ABIN7236090)

限制

仅限研究用
状态

Lyophilized

溶解方式

15 μL or 50 μL double distilled water (DDW), depending on the sample size.

浓度

1 mg/mL

缓冲液

PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
抗原

NPY1R (Neuropeptide Y Receptor Y1 (NPY1R))

别名

NPY1R

背景

Synonyms: Neuropeptide Y receptor type 1, NPYR, NPYY1
Description: Neuropeptide Y1 receptor (NPY1R) is one out of four receptors (NPY1R, NPY2R, NPY4R and NPY5R) that bind neuropeptide Y (NPY), an abundant neuropeptide in the mammalian central and peripheral nervous systems.NPY1R is part of the β-branch of class A G-protein coupled receptors and likewise, has seven transmembrane domains with an extracellular N-terminus and intracellular C-terminal tail1,2.NPY belongs to a family of gut-brain peptides that demonstrate both hormonal functions by paracrine and endocrine release in the gastrointestinal tract and a neurotransmitter functions in sympathetic ganglia and the CNS. It is highly expressed throughout the brain with particularly high expression in limbic brain areas, such as the hippocampus, amygdala, and hypothalamus3,4. NPY modulates multiple physiological and pathophysiological processes: it increases food intake and reduces fear and anxiety by activating NPY1R1,2.Because of the multiple functions of NPY, NPY1R has great importance in the development and progression of both metabolic and neurological diseases such as diabetes, obesity, breast cancer and bone loss and indeed a number of peptides and small-molecule compounds have been characterized as NPY1R antagonists and have shown clinical potential in the treatment of these pathological states5.

基因ID

18166

NCBI登录号

NM_000909

UniProt

Q04573

途径

Negative Regulation of Hormone Secretion, Feeding Behaviour