NPY1R 抗体 (Extracellular) (FITC)
Quick Overview for NPY1R 抗体 (Extracellular) (FITC) (ABIN7237741)
抗原
See all NPY1R 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 197-210, Extracellular
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原理
- A Rabbit Polyclonal Antibody to NPY1R (extracellular) conjugated to the fluorescent dye FITC
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特异性
- 2nd extracellular loop
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat - identical, human - 13,14 amino acid residues identical
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产品特性
- Extracellular, 2nd loop
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: CFDKFPSDSHRLSY, corresponding to amino acid residues 197-210 of mouse NPY1R
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亚型
- IgG
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anti-Neuropeptide Y Receptor Y1 (NPY1R) (AA 301-382) antibody
NPY1R 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptide Y Receptor Y1 (NPY1R) (Middle Region) antibodyNPY1R 适用: 人, 小鼠, 大鼠, 马, 犬, 豚鼠, 兔, Cow, 绵羊 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptide Y Receptor Y1 (NPY1R) (Extracellular Domain) antibodyNPY1R 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptide Y Receptor Y1 (NPY1R) (AA 180-229) antibodyNPY1R 适用: 人, 小鼠, 大鼠, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptide Y Receptor Y1 (NPY1R) (AA 1-115) antibodyNPY1R 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G2 unconjugated
anti-Neuropeptide Y Receptor Y1 (NPY1R) (Internal Region) antibodyNPY1R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptide Y Receptor Y1 (NPY1R) (AA 197-210), (Extracellular) antibodyNPY1R 适用: 小鼠 WB, IHC, IF, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptide Y Receptor Y1 (NPY1R) (Cytoplasmic Domain) antibodyNPY1R 适用: 人, 小鼠, 大鼠, 马, 猴, 犬, 豚鼠, 兔, Bat, Pig IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptide Y Receptor Y1 (NPY1R) (C-Term) antibodyNPY1R 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptide Y Receptor Y1 (NPY1R) (AA 237-252) antibodyNPY1R 适用: 人 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: N/A
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说明
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Negative Control: (ABIN7582044)
Blocking Peptide: (ABIN7236090)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 15 μL or 50 μL double distilled water (DDW), depending on the sample size.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- NPY1R (Neuropeptide Y Receptor Y1 (NPY1R))
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别名
- NPY1R
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背景
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Neuropeptide Y receptor type 1, NPYR, NPYY1,Neuropeptide Y1 receptor (NPY1R) is one out of four receptors (NPY1R, NPY2R, NPY4R and NPY5R) that bind neuropeptide Y (NPY), an abundant neuropeptide in the mammalian central and peripheral nervous systems.NPY1R is part of the β-branch of class A G-protein coupled receptors and likewise, has seven transmembrane domains with an extracellular N-terminus and intracellular C-terminal tail1,2.NPY belongs to a family of gut-brain peptides that demonstrate both hormonal functions by paracrine and endocrine release in the gastrointestinal tract and a neurotransmitter functions in sympathetic ganglia and the CNS. It is highly expressed throughout the brain with particularly high expression in limbic brain areas, such as the hippocampus, amygdala, and hypothalamus3,4. NPY modulates multiple physiological and pathophysiological processes: it increases food intake and reduces fear and anxiety by activating NPY1R1,2.Because of the multiple functions of NPY, NPY1R has great importance in the development and progression of both metabolic and neurological diseases such as diabetes, obesity, breast cancer and bone loss and indeed a number of peptides and small-molecule compounds have been characterized as NPY1R antagonists and have shown clinical potential in the treatment of these pathological states5.
Alternative names: Neuropeptide Y receptor type 1, NPYR, NPYY1 -
基因ID
- 18166
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NCBI登录号
- NM_000909
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UniProt
- Q04573
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途径
- Negative Regulation of Hormone Secretion, Feeding Behaviour
抗原
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