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ACE2 抗体 (Extracellular, N-Term)

The 兔多克隆 anti-ACE2 antibody (ABIN7237591) specifically detects ACE2 in WB, IHC, FACS 和 LCI. The antibody is reactive with 人 samples.

Western blot analysis of rat small intestine lysate (lanes 1 and 4), mouse lung lysate (lanes 2 and 5 ) and mouse kidney lysate (lanes 3 and 6):1-3. (ACE2 抗体 (Extracellular, N-Term))

Cell surface detection of ACE2 by indirect flow cytometry in live intact human monocytic leukemia cell line: + goat-anti-rabbit-FITC. (ACE2 抗体 (Extracellular, N-Term))

FACS

Expression of ACE2 in mouse thalamus. (ACE2 抗体 (Extracellular, N-Term))

IHC

Western blot analysis of human HepG2 hepatoma cell line lysate (lanes 1 and 3) and human monocytic leukemia cell line lysate (lanes 2 and 4):1-2. (ACE2 抗体 (Extracellular, N-Term))

4 images

产品编号 ABIN7237591

发货至: 中国

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Quick Overview for ACE2 抗体 (Extracellular, N-Term) (ABIN7237591)

抗原

See all ACE2 抗体

ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

适用

人

宿主

兔

克隆类型

多克隆

标记

This ACE2 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Discover our top product ACE2 Primary Antibody

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AA 197-213, Extracellular, N-Term

原理

A Rabbit Polyclonal Antibody to ACE2 (extracellular)

交叉反应

人, 小鼠, 大鼠

预测反应

Rat - 14 out of 17 amino acid residues identical,mouse - 13 out of 17 amino acid residues identical

产品特性

Extracellular, N-terminus

纯化方法

Affinity purified on immobilized antigen.

免疫原

(C)EDYGDYWRGDYEVNGVD, corresponding to amino acid residues 197 - 213 of human ACE2

亚型

IgG
anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 601-700) antibody
ACE2 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 18-250) antibody
ACE2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) antibody
ACE2 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal AC18F unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 93-464) antibody
ACE2 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 392-739) antibody
ACE2 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (N-Term) antibody
Verified ACE2 适用: 人 WB, IHC, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 773-805), (C-Term) antibody
ACE2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB4819 unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 140-172) antibody
ACE2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 59-90) antibody
ACE2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 351-450) antibody
ACE2 适用: 人, 小鼠 WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:200
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user

说明

Negative Control: (ABIN7234723)
Blocking Peptide: (ABIN7234723)

限制

仅限研究用
状态

Lyophilized

溶解方式

25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

浓度

0.8 mg/mL

缓冲液

PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
抗原

ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

别名

ACE2

背景

Synonyms: Angiotensin-Converting Enzyme 2, ACE-Related Carboxypeptidase, Angiotensin-converting enzyme homolog, ACEH, Metalloprotease MPROT15
Description: The renin-angiotensin system is a central mechanism for blood pressure regulation through a diverse system of hormones and receptors. Angiotensin-converting enzyme (ACE) is an ectoenzyme that plays a role in the generation of Ang II by catalyzing the extracellular conversion of the decapeptide Ang I. Moreover, ACE degrades active bradykinin (BK), which play an important role in the control of blood pressure. ACE2 is an ACE homolog that was discovered in 2000 when two independent research groups cloned homologous ACE that could convert Ang I to Ang (1-9). Sequence analysis suggests that ACE and ACE2 exhibit 42 % amino acid homology and ACE2 has evolved through gene duplication1.ACE2 consist of N-terminal peptidase domain with seven potential N-linked glycosylation sites that bears the characteristic HEXXH motif of M2 metalloproteases. It is mainly expressed in the small intestine, testis, kidneys, heart, thyroid and adipose tissue and in the lungs. ACE 2 has a protective role in the cardiovascular system and in alveolar epithelial cells. In the lungs ACE2 has numerous physiological functions, most of which are protective against lung injury2. ACE 2 was identified as the receptor for highly pathogenic SARS (severe acute respiratory syndrome) coronavirus including the SARS-CoV-2 that cause the coronavirus disease 2019 (COVID-19) global pandemic. SARS virus binding downregulates the cellular expression of ACE2, and the binding induces clathrin-dependent internalization of virus/receptor (SARS/ACE2) complex. Not only has ACE2 facilitated the invasion of SARS virus for rapid replication, but also ACE2 is depleted from the cell membrane and therefore the damaging effects of Ang II are enhanced, resulting in acute deterioration of lung tissues3.

基因ID

59272

NCBI登录号

NM_001371415

UniProt

Q9BYF1

途径

ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour