GABARAP 抗体 (C-Term)
Quick Overview for GABARAP 抗体 (C-Term) (ABIN7233059)
抗原
See all GABARAP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Anti-GABARAP Rabbit Polyclonal Antibody
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特异性
- This antibody recognizes human and mouse GABARAP.
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交叉反应
- 人, 小鼠
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免疫原
- Synthetic peptide corresponding to the C-terminus of human GABARAP
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anti-GABA(A) Receptor-Associated Protein (GABARAP) (AA 1-100) antibody
GABARAP 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-GABA(A) Receptor-Associated Protein (GABARAP) (AA 1-30) antibodyGABARAP 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB11846 unconjugated
anti-GABA(A) Receptor-Associated Protein (GABARAP) (AA 1-30) antibodyGABARAP 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-GABA(A) Receptor-Associated Protein (GABARAP) (AA 1-31), (N-Term) antibodyGABARAP 适用: 人 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-GABA(A) Receptor-Associated Protein (GABARAP) (AA 1-117) antibodyGABARAP 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-GABA(A) Receptor-Associated Protein (GABARAP) (N-Term) antibodyGABARAP 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-GABA(A) Receptor-Associated Protein (GABARAP) (N-Term) antibody (HRP)GABARAP 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal HRP
anti-GABA(A) Receptor-Associated Protein (GABARAP) (N-Term) antibody (FITC)GABARAP 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal FITC
anti-GABA(A) Receptor-Associated Protein (GABARAP) (N-Term) antibody (Biotin)GABARAP 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal Biotin
anti-GABA(A) Receptor-Associated Protein (GABARAP) (N-Term) antibody (PE)GABARAP 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal PE
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应用备注
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Immunoblotting: use at dilution of 1:1,000. A band of ~14-16 kDa is detected. Other bands observed at ~40 kDa (complex) and ~26 kDa (dimer).
Immunofluorescence: use at dilution of 1:100
These are recommended working dilutions.
Endusers should determine optimal dilutions for their applications. -
限制
- 仅限研究用
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状态
- Liquid
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溶解方式
- Dilute in PBS or medium that is identical to that used in the assay system.
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浓度
- 1.0 mg/mL
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缓冲液
- PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- This antibody is stable for at least one (1) year at -20°C.
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- GABARAP (GABA(A) Receptor-Associated Protein (GABARAP))
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别名
- GABARAP
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背景
- γ-aminobutyric acid receptor-associated protein,Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton (PubMed:9892355). Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:15169837, PubMed:20562859, PubMed:22948227). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538). Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction (PubMed:25684205). Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation (PubMed:25684205). Involved in apoptosis (PubMed:15977068). {PubMed:15169837, PubMed:15977068, PubMed:20562859, PubMed:22948227, PubMed:25684205, PubMed:31006538, PubMed:9892355}.,Gamma-aminobutyric acid A receptors (GABA(A) receptors) are ligand-gated chloride channels that mediate inhibitory neurotransmission. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. In addition, GABARAP has an important role in autophagy, it is crucial for autophagosome formation and sequestering cytosolic cargo into double-membrane vesicles which is then followed by degradation after fusion with lysosomes.,Cytoplasmic vesicle, autophagosome membrane, Endomembrane system, Cytoplasm, cytoskeleton, Golgi apparatus membrane, Cytoplasmic vesicle,GABA(A receptor-associated protein, MM46
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UniProt
- O95166
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途径
- Autophagy
抗原
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