GCET2 抗体
Quick Overview for GCET2 抗体 (ABIN7232905)
抗原
See all GCET2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-HGAL Mouse Monoclonal Antibody
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特异性
- This antibody recognizes human HGAL.
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交叉反应
- 人
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免疫原
- GST-HGAL fusion protein (Accession no. AF521911)
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亚型
- IgG2a
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anti-Germinal Center Expressed Transcript 2 (GCET2) (AA 1-178) antibody
GCET2 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1E9 unconjugated
anti-Germinal Center Expressed Transcript 2 (GCET2) (AA 31-130) antibodyGCET2 适用: 小鼠 ELISA, WB, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Germinal Center Expressed Transcript 2 (GCET2) (AA 1-178) antibodyGCET2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Germinal Center Expressed Transcript 2 (GCET2) antibodyGCET2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Germinal Center Expressed Transcript 2 (GCET2) antibodyGCET2 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Germinal Center Expressed Transcript 2 (GCET2) (AA 1-178) antibodyGCET2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Germinal Center Expressed Transcript 2 (GCET2) (C-Term) antibodyGCET2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry: use at 1-10 μg/mL on paraffin-embedded tissues with heat-induced antigen retrieval in citrate buffer (10 mM, pH 6.0, 10 minutes).
Immunoblotting: use at 1-10 μg/mLHGAL mRNA and protein expression in lysates of indicated cell lines. Actin served as a loading control.
These are recommended concentrations.
Endusers should determine optimal concentrations for their applications. -
限制
- 仅限研究用
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状态
- Liquid
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溶解方式
- Dilute in PBS or medium that is identical to that used in the assay system.
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浓度
- Lot specific
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缓冲液
- PBS, pH 7.4
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储存条件
- -20 °C
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储存方法
- This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
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- GCET2 (Germinal Center Expressed Transcript 2 (GCET2))
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别名
- GCSAM
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背景
- Germinal center-associated signaling and motility protein,Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. {PubMed:17823310, PubMed:20844236, PubMed:23299888}.,The human germinal-center-associated lymphoma (HGAL) gene was originally identified from an expressed sequence tag that was associated with improved survival in patients with diffuse large B-cell lymphoma (DLBCL). Cloning and characterization of HGAL indicated that it is induced by IL-4. HGAL is a cytoplasmic protein and has been demonstrated in follicular lymphoma, Burkitt lymphoma, lymphocyte-predominant Hodgkin lymphoma, and a subset of DLBCL. HGAL expression is an important predictor of overall survival in patients with germinal center- derived tumors. HGAL protein is also found in germinal centers of normal tonsils and lymph nodes.,Cytoplasm. Cell membrane. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.,Germinal center B-cell-expressed transcript 2 protein, Germinal center-associated lymphoma protein, hGAL
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UniProt
- Q8N6F7
抗原
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