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ACE2 抗体 (AA 406-677)

Name: ACE2 抗体 (AA 406-677)
SKU: ABIN7232878
Availability: OutOfStock

This anti-ACE2 antibody is a 兔多克隆 antibody detecting ACE2 in WB. Suitable for 人.

产品编号 ABIN7232878

发货至: 中国

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中国
北京 101111

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Quick Overview for ACE2 抗体 (AA 406-677) (ABIN7232878)

抗原

See all ACE2 抗体

ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

适用

人

宿主

兔

克隆类型

多克隆

标记

This ACE2 antibody is un-conjugated

应用范围

Western Blotting (WB)

Discover our top product ACE2 Primary Antibody

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AA 406-677

原理

Anti-Angiotensin Converting Enzyme 2 (ACE2) Rabbit Polyclonal Antibody

特异性

Human ACE2.

交叉反应

人

免疫原

Recombinant protein corresponding to aa 406-677of human ACE2 protein.
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ACE2 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal AC18F unconjugated

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ACE2 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 392-739) antibody
ACE2 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (N-Term) antibody
Verified ACE2 适用: 人 WB, IHC, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 773-805), (C-Term) antibody
ACE2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB4819 unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 59-90) antibody
ACE2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 140-172) antibody
ACE2 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 351-450) antibody
ACE2 适用: 人, 小鼠 WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

Immunoblotting: use at dilution of 1:1,000. A band of ~92 kDa is detected. Detection of ACE2 in Hela cell lysate (30 μg) with #19505 diluted 1:1,000.

限制

仅限研究用
状态

Liquid

溶解方式

Dilute in PBS or medium that is identical to that used in the assay system.

浓度

0.73 mg/mL

缓冲液

0.1M Tris, 0.1M Glycine, 20 % glycerol, 0.01 % Thimerosal.

储存液

Thimerosal (Merthiolate)

注意事项

This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

This antibody is stable for at least one (1) year at -20°C.
抗原

ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

别名

ACE2

背景

Angiotensin-converting enzyme 2,Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed:27217402). Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed:10969042, PubMed:10924499, PubMed:11815627, PubMed:19021774, PubMed:14504186). Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin (PubMed:10969042, PubMed:11815627). Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency (PubMed:11815627, PubMed:27217402, PubMed:28293165). In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity (PubMed:18424768, PubMed:19185582). {PubMed:10924499, PubMed:10969042, PubMed:11815627, PubMed:14504186, PubMed:18424768, PubMed:19021774, PubMed:19185582, PubMed:27217402}., [Isoform 2]: Non-functional as a carboxypeptidase. {PubMed:33077916}., (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. {PubMed:14647384, PubMed:15452268, PubMed:15791205, PubMed:15897467, PubMed:19901337, PubMed:24227843, PubMed:32142651, PubMed:32155444, PubMed:32221306, PubMed:32225175, PubMed:33000221, PubMed:33082294, PubMed:33432067}., [Isoform 2]: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2. {PubMed:33077916, PubMed:33432184}.,[Processed angiotensin-converting enzyme 2]: Secreted, Cytoplasm, Cell projection, cilium, Apical cell membrane

基因ID

300335

UniProt

Q9BYF1

途径

ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour