ZCCHC11 抗体
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Quick Overview for ZCCHC11 抗体 (ABIN7231968)
抗原
See all ZCCHC11 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- TUT4 Polyclonal Antibody
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特异性
- The antibody detects endogenous levels of TUT4 protein
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen
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免疫原
- Synthesized peptide derived from part region of human TUT4 protein
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亚型
- IgG
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anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (AA 1-290) antibody
ZCCHC11 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (Internal Region) antibodyZCCHC11 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (AA 1403-1452) antibodyZCCHC11 适用: 人, 犬, Cow, 豚鼠, Bat, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (Internal Region) antibodyVerified ZCCHC11 适用: 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (C-Term) antibodyVerified ZCCHC11 适用: 人 ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (AA 1-309) antibodyZCCHC11 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (AA 1568-1600), (C-Term) antibodyZCCHC11 适用: 小鼠 WB 宿主: 兔 Polyclonal RB51164 unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (AA 1-309) antibodyZCCHC11 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (Middle Region) antibodyZCCHC11 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- ZCCHC11 (Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))
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别名
- TUT4
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背景
- Rabbit Anti-TUT4 Polyclonal Antibody,Terminal uridylyltransferase 4, TUTase 4, Zinc finger CCHC domain-containing protein 11,ZCCHC11 is an RNA uridyltransferase (EC 2.7.7.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules. GO annotations related to this gene include nucleic acid binding and nucleotidyltransferase activity. Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay. Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency. Does not bind RNA directly, but recruited to RNA targets by RNA-binding protein LIN28A. Also catalyzes the 3 uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.,TUT4
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分子量
- observerd band 180kDa
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基因ID
- 23318
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UniProt
- Q5TAX3
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途径
- Stem Cell Maintenance
抗原
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