TARDBP 抗体 (AA 41-90)
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Quick Overview for TARDBP 抗体 (AA 41-90) (ABIN7231678)
抗原
See all TARDBP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 41-90
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原理
- Rabbit Anti-TADBP Polyclonal Antibody
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特异性
- The antibody detects endogenous levels of TADBP protein
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthesized peptide derived from part region of human TADBP protein at AA range: 41-90
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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有效期
- 12 months
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- TARDBP (TAR DNA Binding Protein (TARDBP))
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别名
- TADBP
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背景
- TAR DNA-binding protein 43, TDP-43HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by TARDBP is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
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分子量
- 45kD
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基因ID
- 23435
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UniProt
- Q13148
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途径
- Positive Regulation of Peptide Hormone Secretion
抗原
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