RNF111 抗体 (AA 870-950)
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北京 101111
Quick Overview for RNF111 抗体 (AA 870-950) (ABIN7223318)
抗原
See all RNF111 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 870-950
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原理
- Arkadia Polyclonal Antibody
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特异性
- Arkadia Polyclonal Antibody detects endogenous levels of Arkadia protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from the C-terminal region of human Arkadia at AA range: 870-950
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- RNF111 (Ring Finger Protein 111 (RNF111))
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别名
- Arkadia
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背景
- Rabbit Anti-Arkadia Polyclonal Antibody,RNF111, E3 ubiquitin-protein ligase Arkadia, RING finger protein 111,The protein encoded by RNF111 (ring finger protein 111) is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF)-beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, RNF111 plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of RNF111 results in multiple transcript variants encoding distinct isoforms.,E3 ubiquitin-protein ligase Arkadia
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基因ID
- 54778
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UniProt
- Q6ZNA4
抗原
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