OPRK1 抗体 (AA 290-370)
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Quick Overview for OPRK1 抗体 (AA 290-370) (ABIN7222868)
抗原
See all OPRK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 290-370
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原理
- Rabbit Anti-KOR-1 Polyclonal Antibody
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特异性
- KOR-1 Polyclonal Antibody detects endogenous levels of KOR-1 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthesized peptide derived from the C-terminal region of human KOR-1 at AA range: 290-370
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300,ELISA 1:2000-20000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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有效期
- 12 months
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- OPRK1 (Opioid Receptor, kappa 1 (OPRK1))
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别名
- KOR-1
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背景
- OPRK1, OPRK, Kappa-type opioid receptor, K-OR-1, KOR-1OPRK1 encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in OPRK1 have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
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分子量
- 48kD
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基因ID
- 4986
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UniProt
- P41145
抗原
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