NEURL 抗体 (pTyr1221)
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北京 101111
Quick Overview for NEURL 抗体 (pTyr1221) (ABIN7213314)
抗原
See all NEURL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr1221
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原理
- Neu (phospho Tyr1221/Y1222) Polyclonal Antibody
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特异性
- Phospho-Neu (Y1221/Y1222) Polyclonal Antibody detects endogenous levels of Neu protein only when phosphorylated at Y1221/Y1222.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from human Neu Phospho-Tyr1221/Y1222
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亚型
- IgG
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anti-Neuralized Homolog (Drosophila) (NEURL) (Internal Region) antibody
NEURL 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neuralized Homolog (Drosophila) (NEURL) (pTyr1248) antibodyNEURL 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuralized Homolog (Drosophila) (NEURL) (Internal Region) antibodyNEURL 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuralized Homolog (Drosophila) (NEURL) (Ser357) antibodyNEURL 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuralized Homolog (Drosophila) (NEURL) (Center) antibodyNEURL 适用: 人 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Neuralized Homolog (Drosophila) (NEURL) (AA 158-186) antibodyNEURL 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB21920 unconjugated
anti-Neuralized Homolog (Drosophila) (NEURL) (AA 107-156) antibodyNEURL 适用: 人, 小鼠, 大鼠, 猴, Cow, 犬, 豚鼠, 马, 兔, Bat, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Neuralized Homolog (Drosophila) (NEURL) (pTyr1112) antibodyNEURL 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neuralized Homolog (Drosophila) (NEURL) (pTyr1221), (pTyr1222) antibodyNEURL 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Neuralized Homolog (Drosophila) (NEURL) (pTyr877) antibodyNEURL 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:40000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- NEURL (Neuralized Homolog (Drosophila) (NEURL))
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别名
- Neu
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背景
- Rabbit Anti-Neu (phospho Tyr1221/Y1222) Polyclonal Antibody,ERBB2, HER2, MLN19, NEU, NGL, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD antigen CD340,ERBB2 encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. Erb-b2 receptor tyrosine kinase 2 has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of ERBB2 has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.,Receptor tyrosine-protein kinase erbB-2
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分子量
- observerd band 180kDa
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基因ID
- 2064
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UniProt
- P04626
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途径
- Notch Signaling, EGFR Signaling Pathway
抗原
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