MAP3K4 抗体 (AA 1250-1330)
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Quick Overview for MAP3K4 抗体 (AA 1250-1330) (ABIN7222446)
抗原
See all MAP3K4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1250-1330
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原理
- MEK Kinase-4 Polyclonal Antibody
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特异性
- MEK Kinase-4 Polyclonal Antibody detects endogenous levels of MEK Kinase-4 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from the C-terminal region of human MEK Kinase-4 at AA range: 1250-1330
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亚型
- IgG
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anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) antibody
MAP3K4 适用: 人 IHC, WB 宿主: 兔 Monoclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (AA 1-100) antibodyMAP3K4 适用: 人 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (AA 1201-1300) antibodyMAP3K4 适用: 人 ELISA, WB, IHC (p) 宿主: 小鼠 Monoclonal 4F10 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (AA 1201-1300) antibodyMAP3K4 适用: 人 ELISA, WB, PLA 宿主: 小鼠 Monoclonal 6A12 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (AA 53-145) antibodyMAP3K4 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) antibodyMAP3K4 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB4045 unconjugated Recombinant Antibody
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (AA 1201-1300) antibodyMAP3K4 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 5D4 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (N-Term) antibodyMAP3K4 适用: 人, 小鼠 IHC, ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (C-Term) antibodyMAP3K4 适用: 人, 小鼠, 大鼠 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (AA 1065-1097), (Middle Region) antibodyMAP3K4 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), ELISA (1:5000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- MAP3K4 (Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))
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别名
- MEK Kinase-4
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背景
- Rabbit Anti-MEK Kinase-4 Polyclonal Antibody,MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1, Mitogen-activated protein kinase kinase kinase 4, MAP three kinase 1, MAPK/ERK kinase kinase 4, MEK kinase 4, MEKK 4,The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described.,Mitogen-activated protein kinase kinase kinase 4
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基因ID
- 4216
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UniProt
- Q9Y6R4
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途径
- MAPK Pathway
抗原
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