LRP3 抗体 (AA 30-110)
Quick Overview for LRP3 抗体 (AA 30-110) (ABIN7222266)
抗原
See all LRP3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 30-110
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原理
- LRP3 Polyclonal Antibody
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特异性
- LRP3 Polyclonal Antibody detects endogenous levels of LRP3 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from the N-terminal region of human LRP3 at AA range: 30-110
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- LRP3 (Low Density Lipoprotein Receptor-Related Protein 3 (LRP3))
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别名
- LRP3
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背景
- Rabbit Anti-LRP3 Polyclonal Antibody,LRP3, Low-density lipoprotein receptor-related protein 3, LRP-3, 105 kDa low-density lipoprotein receptor-related protein, hLRp105,NLRP3, also known as NALP3, CIAS1, PYPAF or Cryopyrin, is a cytosolic ~120 kDa member of the NLRP family of proteins expressed in leukocytes, especially neutrophils. As a component of the inflammasome, NLRP3 activates caspases 1 and 5. Defects in NLRP3 may cause FCAS1, CINCA, or Muckle-Wells autoinflammatory syndromes. Mouse NLRP3 contains an N-terminal Pyrin domain (aa 1-91) followed by a Nacht region (aa 216-532), and seven LRRs (aa 739-988). Within the sequence used as an immunogen, mouse NLRP3 shares 78 % and 93 % aa identity with human and rat NLRP3, respectively. Alternate splicing of mouse NLRP3 generates additional isoforms that lack either LRR2 and 3, LRR 6 and 7, or LRR4-9.,Low-density lipoprotein receptor-related protein 3
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分子量
- observerd band 80kDa
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基因ID
- 4037
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UniProt
- O75074
抗原
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