DDIT3 抗体
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北京 101111
Quick Overview for DDIT3 抗体 (ABIN7214200)
抗原
See all DDIT3 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- CHOP Polyclonal Antibody
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特异性
- CHOP Polyclonal Antibody detects endogenous levels of CHOP protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from human CHOP around the non-phosphorylation site of S30
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:5000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))
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别名
- CHOP
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背景
- Rabbit Anti-CHOP Polyclonal Antibody,DDIT3, CHOP, CHOP10, GADD153, DNA damage-inducible transcript 3 protein, DDIT-3, C/EBP-homologous protein, CHOP, C/EBP-homologous protein 10, CHOP-10, Growth arrest and DNA damage-inducible protein GADD153,DDIT3 encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. DNA damage inducible transcript 3 functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.,DNA damage-inducible transcript 3 protein
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分子量
- observerd band 19kDa
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基因ID
- 1649
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UniProt
- P35638
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途径
- Regulation of Muscle Cell Differentiation, ER-Nucleus Signaling, Skeletal Muscle Fiber Development, Cell RedoxHomeostasis
抗原
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