DDIT3 抗体 (N-Term)
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- 抗原 See all DDIT3 抗体
- DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DDIT3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- DDIT3 Antibody detects endogenous levels of total DDIT3.
- 预测反应
- Pig,Bovine,Sheep,Rabbit,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human GADD153, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product DDIT3 Primary Antibody
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anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (C-Term) antibody
DDIT3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (AA 1-169) antibodyDDIT3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (N-Term) antibodyDDIT3 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (pSer30) antibodyDDIT3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (AA 120-149), (C-Term) antibodyDDIT3 适用: 人, 小鼠 WB, IF, FACS 宿主: 兔 Polyclonal RB13788 unconjugated
anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (AA 1-169) antibodyDDIT3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 3 (DDIT3) antibodyDDIT3 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (Ser301) antibodyDDIT3 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 3 (DDIT3) antibodyDDIT3 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (AA 1-90) antibodyDDIT3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G3 unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))
- 别名
- DDIT3 (DDIT3 产品)
- 别名
- chop antibody, Xchop antibody, cebpz antibody, chop10 antibody, gadd153 antibody, CHOP-10 antibody, CHOP10 antibody, CHOP antibody, Chop10 antibody, Gadd153 antibody, CEBPZ antibody, GADD153 antibody, DNA damage inducible transcript 3 antibody, DNA-damage inducible transcript 3 antibody, DNA damage inducible transcript 3 L homeolog antibody, ddit3 antibody, Ddit3 antibody, DDIT3 antibody, ddit3.L antibody
- 背景
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Description: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates, expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
Gene: DDIT3
- 分子量
- 26kDa
- 基因ID
- 1649
- UniProt
- P35638
- 途径
- Regulation of Muscle Cell Differentiation, ER-Nucleus Signaling, Skeletal Muscle Fiber Development, Cell RedoxHomeostasis
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