DHX58 抗体 (AA 451-500)
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Quick Overview for DHX58 抗体 (AA 451-500) (ABIN7228212)
抗原
See all DHX58 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 451-500
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原理
- DHX58 Polyclonal Antibody
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特异性
- The antibody detects endogenous levels of DHX58 protein
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen
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免疫原
- Synthesized peptide derived from part region of human DHX58 protein at AA range: 451-500
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亚型
- IgG
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anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 479-678) antibody
DHX58 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3E11F1 unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 479-678) antibodyDHX58 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 6A6A3 unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 389-678) antibodyDHX58 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (C-Term) antibodyVerified DHX58 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 389-678) antibodyDHX58 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) antibodyDHX58 适用: 人, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (Internal Region) antibodyDHX58 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 1-678) antibodyDHX58 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 1-678) antibodyDHX58 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 35-84) antibodyDHX58 适用: 人, 豚鼠, 马, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- DHX58 (DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))
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别名
- DHX58
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背景
- Rabbit Anti-DHX58 Polyclonal Antibody,Probable ATP-dependent RNA helicase DHX58, Probable ATP-dependent helicase LGP2, Protein D11Lgp2 homolog, RIG-I-like receptor 3, RLR-3, RIG-I-like receptor LGP2, RLR,DHX58 (DExH-Box Helicase 58) is a Protein Coding gene. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Innate Immune System. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is IFIH1. Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5-triphosphorylated RNA, although it can recognize RNA lacking a 5-triphosphate.,DHX58
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分子量
- observerd band 74kDa
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基因ID
- 79132
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UniProt
- Q96C10
抗原
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