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- 抗原 See all DHX58 抗体
- DHX58 (DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))
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适用
- 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DHX58 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 产品特性
- Polyclonal Antibody
- 纯化方法
- Antigen affinity purification
- 免疫原
- Fusion protein of human DHX58
- 亚型
- IgG
- Top Product
- Discover our top product DHX58 Primary Antibody
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anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 479-678) antibody
DHX58 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 3E11F1 unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 479-678) antibodyDHX58 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 6A6A3 unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 389-678) antibodyDHX58 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (C-Term) antibodyVerified DHX58 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 1-678) antibodyDHX58 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (Internal Region) antibodyDHX58 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 389-678) antibodyDHX58 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 1-678) antibodyDHX58 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 35-84) antibodyDHX58 适用: 人, 马, 豚鼠, 猴, Pig, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 41-69), (N-Term) antibodyDHX58 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB26842 unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:100, ELISA 1:5000-1:10000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1.02 mg/mL
- 缓冲液
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- DHX58 (DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))
- 别名
- DHX58 (DHX58 产品)
- 别名
- MGC82787 antibody, DHX58 antibody, lgp2 antibody, D11LGP2 antibody, D11lgp2e antibody, LGP2 antibody, RLR-3 antibody, B430001I08Rik antibody, D11Lgp2e antibody, LPG2 antibody, Lgp2 antibody, RGD1310093 antibody, DEXH-box helicase 58 L homeolog antibody, DExH-box helicase 58 antibody, probable ATP-dependent RNA helicase DHX58 antibody, DEXH (Asp-Glu-X-His) box polypeptide 58 antibody, DEXH-box helicase 58 antibody, dhx58.L antibody, DHX58 antibody, dhx58 antibody, LOC100566102 antibody, Dhx58 antibody
- 背景
- Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
- 分子量
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Observed_MW: Refer to figures
Calculated_MW: 77 kDa
- UniProt
- Q96C10
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