beta Catenin 抗体 (pSer33)
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Quick Overview for beta Catenin 抗体 (pSer33) (ABIN7219816)
抗原
See all beta Catenin (CATNB) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer33
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原理
- Catenin-β (phospho Ser33) Polyclonal Antibody
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特异性
- Phospho-Catenin-β (S33) Polyclonal Antibody detects endogenous levels of Catenin-β protein only when phosphorylated at S33.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from human Catenin-beta Phospho-Ser33
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:10000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- beta Catenin (CATNB) (Catenin, beta (CATNB))
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别名
- Catenin-beta
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背景
- Rabbit Anti-Catenin-β (phospho Ser33) Polyclonal Antibody,CTNNB1, CTNNB, OK/SW-cl.35, Catenin beta-1, Beta-catenin,Catenin beta-1 encoded by CTNNB1 is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.,Catenin beta-1
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分子量
- observerd band 85kDa
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基因ID
- 1499
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UniProt
- P35222
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途径
- Peptide Hormone Metabolism
抗原
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