beta Catenin 抗体 (pSer552)
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Quick Overview for beta Catenin 抗体 (pSer552) (ABIN7213360)
抗原
See all beta Catenin (CATNB) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer552
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原理
- Catenin-β (phospho Ser552) Polyclonal Antibody
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特异性
- Phospho-Catenin-β (S552) Polyclonal Antibody detects endogenous levels of Catenin-β protein only when phosphorylated at S552.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from human Catenin-beta Phospho-Ser552
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- beta Catenin (CATNB) (Catenin, beta (CATNB))
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别名
- Catenin-beta
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背景
- Rabbit Anti-Catenin-β (phospho Ser552) Polyclonal Antibody,CTNNB1, CTNNB, OK/SW-cl.35, Catenin beta-1, Beta-catenin,Catenin beta 1 encoded by CTNNB1 is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Catenin beta 1 also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, catenin beta 1 binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in CTNNB1 are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for CTNNB1.,Catenin beta-1
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基因ID
- 1499
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UniProt
- P35222
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途径
- Peptide Hormone Metabolism
抗原
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