ATOH8 抗体
Our Local Distributor
北京 101111
Quick Overview for ATOH8 抗体 (ABIN7227408)
抗原
See all ATOH8 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- ATOH8 Polyclonal Antibody
-
特异性
- The antibody detects endogenous levels of ATOH8 protein
-
纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen
-
免疫原
- Synthesized peptide derived from part region of human ATOH8 protein
-
亚型
- IgG
-
-
anti-Atonal Homolog 8 (ATOH8) (C-Term) antibody
ATOH8 适用: 人 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Atonal Homolog 8 (ATOH8) (N-Term) antibodyATOH8 适用: 人, Cow, 犬, 马, 兔, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Atonal Homolog 8 (ATOH8) (C-Term) antibodyATOH8 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Atonal Homolog 8 (ATOH8) (AA 10-39), (N-Term) antibodyATOH8 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB33477 unconjugated
anti-Atonal Homolog 8 (ATOH8) (C-Term) antibodyATOH8 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).
-
说明
-
Primary Antibody
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
-
-
- ATOH8 (Atonal Homolog 8 (ATOH8))
-
别名
- ATOH8
-
背景
- Rabbit Anti-ATOH8 Polyclonal Antibody,Protein atonal homolog 8, Class A basic helix-loop-helix protein 21, bHLHa21, Helix-loop-helix protein hATH-6, hATH6,Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5-CANNTG- 3 known as an E-box element, possibly as a heterodimer with other bHLH proteins. Regulates endothelial cell proliferation, migration and tube-like structures formation. Modulates endothelial cell differentiation through NOS3. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation. During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3. During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase. Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex. Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms, requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif.,ATOH8
-
基因ID
- 84913
-
UniProt
- Q96SQ7
-
途径
- Regulation of Muscle Cell Differentiation
抗原
-
