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- 抗原 See all ATOH8 抗体
- ATOH8 (Atonal Homolog 8 (ATOH8))
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抗原表位
- C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ATOH8 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
- 特异性
- ATOH8 Antibody detects endogenous levels of total ATOH8.
- 预测反应
- Pig,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human ATOH8, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
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anti-Atonal Homolog 8 (ATOH8) (N-Term) antibody
ATOH8 适用: 人, Cow, 犬, 马, 兔, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Atonal Homolog 8 (ATOH8) (C-Term) antibodyATOH8 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Atonal Homolog 8 (ATOH8) (AA 10-39), (N-Term) antibodyATOH8 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB33477 unconjugated
anti-Atonal Homolog 8 (ATOH8) (C-Term) antibodyATOH8 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, IF/ICC 1:100-1:500 IHC : 1:50-200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- ATOH8 (Atonal Homolog 8 (ATOH8))
- 别名
- ATOH8 (ATOH8 产品)
- 别名
- ath6 antibody, zgc:158314 antibody, ATOH8 antibody, HATH6 antibody, bHLHa21 antibody, 4933425C05Rik antibody, Hath6 antibody, Math6 antibody, okadin antibody, RGD1561512 antibody, atonal bHLH transcription factor 8 antibody, atoh8 antibody, ATOH8 antibody, Atoh8 antibody
- 背景
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Description: Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (PubMed:24236640). Regulates endothelial cell proliferation, migration and tube-like structures formation (PubMed:24463812). Modulates endothelial cell differentiation through NOS3 (PubMed:24463812). May be implicated in specification and differentiation of neuronal cell lineages in the brain (By similarity). May participate in kidney development and may be involved in podocyte differentiation (By similarity). During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3 (By similarity). During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase (By similarity). Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex (PubMed:24236640). Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms, requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif (By similarity).
Gene: ATOH8
- 分子量
- 35 kDa
- 基因ID
- 84913
- UniProt
- Q96SQ7
- 途径
- Regulation of Muscle Cell Differentiation
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