AKT1/3 (pTyr434), (pTyr437) 抗体
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Quick Overview for AKT1/3 (pTyr434), (pTyr437) 抗体 (ABIN7213280)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr434, pTyr437
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原理
- Akt1/3 (phospho Tyr437/434) Polyclonal Antibody
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特异性
- Phospho-Akt1/3 (Y437/434) Polyclonal Antibody detects endogenous levels of Akt1/3 protein only when phosphorylated at Y437/434.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from human Akt1/3 Phospho-Tyr437/434
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亚型
- IgG
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anti-AKT1/3 (AA 401-479) antibody
适用: 人, 小鼠, 大鼠 ELISA, WB, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 小鼠 Polyclonal unconjugated
anti-AKT1/3 (pTyr434), (pTyr437) antibody适用: 小鼠, 大鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-AKT1/3 (Lys539) antibody适用: 人, 小鼠, 大鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-AKT1/3 (AA 406-455), (pTyr437) antibody适用: 人, 小鼠, 大鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-AKT1/3 (Tyr434), (Tyr437) antibody适用: 人, 小鼠, 大鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- AKT1/3
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背景
- Rabbit Anti-Akt1/3 (phospho Tyr437/434) Polyclonal Antibody,AKT1, PKB, RAC, RAC-alpha serine/threonine-protein kinase, Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT3, PKBG, RAC-gamma serine/threonine-protein kinase, Protein kinase Akt-3, Protein ki,The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in AKT1 have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for AKT1.,RAC-alpha serine threonine-protein kinase
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基因ID
- 207, 10000
抗原
-
