Sclerostin 抗体
Quick Overview for Sclerostin 抗体 (ABIN715586)
抗原
See all Sclerostin (SOST) 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 犬, 人, 小鼠, Pig, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Sclerostin
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亚型
- IgG
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anti-Sclerostin (SOST) (AA 12-42), (N-Term) antibody
SOST 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB12388 unconjugated
anti-Sclerostin (SOST) (AA 25-213) antibodySOST 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sclerostin (SOST) (AA 24-213) antibodySOST 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Sclerostin (SOST) (AA 24-213) antibodySOST 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Sclerostin (SOST) (AA 121-180) antibodySOST 适用: 人, 小鼠, 大鼠, 兔 WB, ELISA, ICC, IF (p), IHC (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Sclerostin (SOST) (N-Term) antibodySOST 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Sclerostin (SOST) (AA 25-209) antibodySOST 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sclerostin (SOST) (C-Term) antibodyVerified SOST 适用: 人 IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Sclerostin (SOST) (AA 38-87) antibodySOST 适用: 人, 犬, Pig, 马, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sclerostin (SOST) (AA 134-163) antibodySOST 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB13011 unconjugated
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应用备注
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WB(1:100-500)
Optimal working dilution should be determined by the investigator. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- Sclerostin (SOST)
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别名
- Sclerostin
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背景
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Synonyms: BEER, Cortical hyperostosis with syndactyly, Sclerosteosis, Sclerostin, SOST, SOST_HUMAN, VBCH.
Background: Negative regulator of bone growth.Sclerostin (SOST) is a bone morphogenetic protein (BMP) antagonist, leading to the activation of BMP signaling. It negatively regulates the formation of bone by repressing the differentiation and/or function of osteoblasts induced by BMPs. It has been shown that Sclerostin binds BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity. The noggin-sclerostin protein complex represents a novel mechanism for the fine-tuning of BMP activity in bone homeostasis. Evidence is accumulating that one of the important mechanisms of bone regulation by sclerostin is the modulation of Wnt/Beta-catenin signaling. Sclerostin also rapidly activated ERK-1/2 MAPK signaling, indicating the involvement of additional signaling pathways.
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分子量
- 24-28kDa
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基因ID
- 50964
抗原
-
