HLA-C 抗体 (AA 25-308)
Quick Overview for HLA-C 抗体 (AA 25-308) (ABIN7193962)
抗原
See all HLA-C 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 25-308
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原理
- HLA-C Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human HLA-C (AA: 25-308) expressed in E. Coli.
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亚型
- IgG1
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anti-Major Histocompatibility Complex Class I C (HLA-C) (AA 25-308) antibody
HLA-C 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex Class I C (HLA-C) (AA 62-306) antibodyHLA-C 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex Class I C (HLA-C) (AA 38-62), (C-Term) antibodyHLA-C 适用: 人 WB, IHC, FACS, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex Class I C (HLA-C) (AA 200-306) antibodyHLA-C 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex Class I C (HLA-C) (AA 1-366) antibodyHLA-C 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex Class I C (HLA-C) antibodyHLA-C 适用: 人, Non-Human Primate FACS, IP 宿主: 小鼠 Monoclonal DT-9 unconjugated
anti-Major Histocompatibility Complex Class I C (HLA-C) antibody (PE)HLA-C 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal DT-9 PE
anti-Major Histocompatibility Complex Class I C (HLA-C) (AA 25-308) antibody (Biotin)HLA-C 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal Biotin
anti-Major Histocompatibility Complex Class I C (HLA-C) (AA 1-366) antibodyHLA-C 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Major Histocompatibility Complex Class I C (HLA-C) (AA 208-257) antibodyHLA-C 适用: 人, 犬 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- ELISA: 1/10000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- HLA-C (Major Histocompatibility Complex Class I C (HLA-C))
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别名
- HLA-C
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背景
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HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. About 6000 HLA-C alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.
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分子量
- 40.6 kDa
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UniProt
- P10321
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
抗原
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