Perforin 1 抗体 (AA 148-372)
Quick Overview for Perforin 1 抗体 (AA 148-372) (ABIN7193868)
抗原
See all Perforin 1 (PRF1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 148-372
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原理
- PRF1 Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human PRF1 (AA: 148-372) expressed in E. Coli.
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亚型
- IgG1
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
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别名
- PRF1
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背景
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This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood.
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分子量
- 61.3 kDa
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基因ID
- 5551
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UniProt
- P14222
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途径
- Apoptosis, Caspase Cascade in Apoptosis
抗原
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