IL4 Receptor 抗体 (AA 26-232)
Quick Overview for IL4 Receptor 抗体 (AA 26-232) (ABIN7193555)
抗原
See all IL4 Receptor (IL4R) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 26-232
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原理
- CD124 Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human CD124 (AA: 26-232) expressed in E. Coli.
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亚型
- IgG2b
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))
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别名
- CD124
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背景
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This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
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分子量
- 89.7 kDa
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基因ID
- 3566
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UniProt
- P24394
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途径
- JAK/STAT Signaling, Positive Regulation of Immune Effector Process
抗原
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