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MLH1 抗体 (AA 381-483)

Name: MLH1 抗体 (AA 381-483)
Brand: antibodies-online
SKU: ABIN7193525
Availability: OutOfStock

This anti-MLH1 antibody is a 小鼠单克隆 antibody detecting MLH1 in ELISA, ICC 和 FACS. Suitable for 人.

Western blot analysis using MLH1 mAb against human MLH1 (AA: 381-483) recombinant protein. (MLH1 抗体 (AA 381-483))

Immunofluorescence analysis of Hela cells using MLH1 mouse mAb (green). (MLH1 抗体 (AA 381-483))

Black line: Control Antigen (100 ng),Purple line: Antigen (10 ng), Blue line: Antigen (50 ng), Red line:Antigen (100 ng) (MLH1 抗体 (AA 381-483))

ELISA

Western blot analysis using MLH1 mAb against HEK293 (1) and MLH1 (AA: 381-483)-hIgGFc transfected HEK293 (2) cell lysate. (MLH1 抗体 (AA 381-483))

Flow cytometric analysis of Hela cells using MLH1 mouse mAb (green) and negative control (red). (MLH1 抗体 (AA 381-483))

FACS

Immunofluorescence analysis of Hela cells using MLH1 mouse mAb. (MLH1 抗体 (AA 381-483))

6 images

产品编号 ABIN7193525

发货至: 中国

Quick Overview for MLH1 抗体 (AA 381-483) (ABIN7193525)

抗原

See all MLH1 抗体

MLH1 (MutL Homolog 1 (MLH1))

适用

人

宿主

小鼠

克隆类型

单克隆

标记

This MLH1 antibody is un-conjugated

应用范围

ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

克隆位点

8C12B7

Discover our top product MLH1 Primary Antibody

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AA 381-483

原理

MLH1 Antibody

纯化方法

Purified antibody

免疫原

Purified recombinant fragment of human MLH1 (AA: 381-483) expressed in E. Coli.

亚型

IgG2b
anti-MutL Homolog 1 (MLH1) (AA 1-756) antibody
MLH1 适用: 人 WB, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal M1 unconjugated

anti-MutL Homolog 1 (MLH1) (AA 381-483) antibody
MLH1 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 7A7C8 unconjugated

anti-MutL Homolog 1 (MLH1) (AA 350-519) antibody
MLH1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-MutL Homolog 1 (MLH1) (AA 381-483) antibody
MLH1 适用: 人, 猴 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 4C9C7 unconjugated

anti-MutL Homolog 1 (MLH1) (Internal Region) antibody
MLH1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-MutL Homolog 1 (MLH1) antibody
MLH1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-MutL Homolog 1 (MLH1) (AA 501-600) antibody
MLH1 适用: 人 ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-MutL Homolog 1 (MLH1) (Internal Region) antibody
MLH1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-MutL Homolog 1 (MLH1) (AA 373-735) antibody
MLH1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-MutL Homolog 1 (MLH1) (AA 452-480) antibody
MLH1 适用: 人 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated

应用备注

ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/200 - 1/1000

限制

仅限研究用
状态

Liquid

缓冲液

Purified antibody in PBS with 0.05 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
抗原

MLH1 (MutL Homolog 1 (MLH1))

别名

MLH1

背景

The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).

分子量

84.6 kDa

基因ID

4292

UniProt

P40692

途径

DNA Damage Repair, Production of Molecular Mediator of Immune Response